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The Food and Drug Administration ( FDA ) recently approved a new drug to treatlow sex drive in woman .
But how exactly does the drug work , and what makes it unlike from the other medicine on the market ?
The drug , shout bremelanotide ( brand name Vyleesi ) has been approved to treat premenopausal women with underactive intimate desire disorderliness ( HSDD ) , a shape in which low sexual desire make personal distress , the FDAsaid in a program line . It is only the second FDA - okay drug for HSDD in woman .
woman self - mete out the shot under the pelt of the abdomen or second joint at least 45 arcminute before anticipated sexual activity . Women should not take more than one dose of bremelanotide within a 24 - hour stop or more than eight doses per month . [ 5 Myths About Women ’s Bodies ]
In a study of more than 1,200 premenopausal women with HSDD , 25 % of those who took bremelanotide saw some improvements in their report intimate desire scores , compared with 17 % who took a placebo .
Bremelanotide binds to receptor in the brain called melanocortin receptors , whichplay a role in many biological functions , such as metabolism and food for thought inspiration , skin pigmentation and pain regulation . But it ’s unclear exactly how the drug run to supercharge sexual desire , the FDA said .
However , the main theory is that bremelanotide works by increasingdopamine — a brain chemical involved in reward processing — in sealed parts of the brain , said Sheryl Kingsberg , chief of the Division of Behavioral Medicine at University Hospitals Cleveland Medical Center , who has learn bremelanotide . This , in turn , allows cleaning woman to " treat erotic input as rewarding , " said Kingsberg , who has take in consulting payments from AMAG Pharmaceuticals , which markets Vyleesi , and Palatin Technologies , which developed the drug .
Kingsberg told Live Science that it ’s speculate that normal intimate single-valued function bank on a Libra of excitatory and inhibitory signals in the brain , and HSDD is the result of either not enough excitation or too much prohibition . Within this line of thinking , bremelanotide is hypothesized to promote the excitation response by releasing Intropin , she enounce .
The only other FDA - sanction drug for HSDD isflibanserin(brand name Addyi ) . Flibanserin acts on a different brain receptor , and it partially blocks the production of the brain chemical serotonin , Kingsberg said . Serotonin is think to muffle sexual practice drive in part by inhibiting the excitatory dopamine system , according to a 2017 review inThe Journal of Sexual Medicine .
The two drugs also differ in their dose frequence — flibanserin call for to be take every mean solar day at bedtime , while bremelanotide is taken as needed . drug used to handle male intimate dysfunction , such as sildenafil ( brand name name Viagra ) , mainly target an enzyme called phosphodiesterase 5 ( PDE5 ) , which plays a function in influence blood flow to the phallus . By blockade the enzyme , sildenafil ’s overall issue is to increase descent flow to the penis , which leads to an erection . However , sildenafil does not boost sex drive .
The most vernacular side result of flibanserin are sleepiness and lightheadedness , while the most common side effect of bremelanotide is sickness , Kingsberg say .
In studies of bremelanotide , 40 % of women experienced nausea , most commonly with their first injection of the drug , and 13 % needed to take treatments for their sickness , the FDA read . Still , more than 90 % of women who experienced nausea stayed in the drug trial , suggesting that either their nausea was soft or they feel that the benefit of the drug overbalance the side effect , Kingsberg order .
Bremelanotide should n’t be used in people with uncontrolledhigh blood pressureor those with heart disease , the FDA says . In addition , patient should quit taking bremelanotide after eight weeks if they do n’t see an improvement in their sexual desire and related to distress .
Originally print onLive skill .
